Easwari Rao's debut movie was Intinta Deepavali (1990) in Telugu; she came to prominence in Telugu with the film Rambantu alongside Rajendra Prasad. She debuted in Tamil in Kavithai Paadum Alaigal (1990) credited as Janani. Though the songs were popular, the movie was a failure in the box office. She got her first major break in Raman Abdullah (1997), directed by Balu Mahendra, where she was credited as Easwari Rao. She notably opted out of a project titled Koottaali as she felt the role was too glamorous. She went on to appear in Manoj Kumar's film Guru Paarvai (1998). Easwari also had a role in Bharathiraja's Siragugal Murivadhilai, although the film was shelved after pre-production. In the Tamil film Appu (2000) she portrayed Prasanth's sister. She received praise for her performance as Selvi in Kaala (2018).
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